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Work from Robert Malenka's laboratory demonstrated something unexpected
In a phase 2 clinical trial conducted on an obese population, over a 26-week period, patients who were administered a dose range of efinopegdutide from 5 mg to 10 mg experienced a weight reduction of up to 11.8%
The role of GLP-1 in the nervous system remains inconclusive, yet indicates its potential for alleviating neuroinflammation, safeguarding neurons and glial cells from oxidative damage, and optimizing neurotransmitter equilibrium [83]
Zara Cosentino, commenting on the committee's composition, said that while disclosure requirements represent a positive transparency measure, the situation creates a structural problem "especially when the people who stand to gain from growing access are the ones making the decision." Attorneys at Orrick, analyzing the committee before the meeting, concluded that the most probable outcome was that PCAC would recommend inclusion for some or all of the seven peptides calling it "a significant departure from prior PCAC precedent." Their prediction was accurate to the letter
