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FDA Approval Timeline: From Diabetes to Weight Loss (1990s2020s) The first GLP-1 receptor agonist, exenatide, received FDA approval in 2005 specifically for type 2 diabetes management

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By Sujith Ramachandran and Liang-Yuan (Claire) Lin If you watched the Super Bowl in 2026, you likely saw Serena Williams share her weight loss journey on GLP-1 medications in a commercial