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TME-mediated cancer resistance and combating strategies The TME in cancer resistance The TME constitutes a critical layer of therapeutic resistance in which immune and stromal cells, extracellular matrix remodeling, and vascularmetabolic constraints jointly restrict drug and immune efficacy (Fig
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doi: 10.26355/eurrev_201906_18072 197 ChenYWangWChenYTangQZhuWLiDet al
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