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In 2024, the FDA also approved it for reducing cardiovascular risk in adults with obesity or who are overweight
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In the Liraglutide Effect and Action in Diabetes trial (LEAD-3), GLP-1RA liraglutide treatment significantly reduced body fat, but there was no significant change in lean body mass
While no universal standard exists for assigning edge weights in comorbidity networks, our approach follows established practices in network medicine, where higher weights are given to interactions between nodes that are functionally or mechanistically critical 67,68
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