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doi: 10.1016/j.clinre.2016.11.009 Summary Keywords glucagon-like peptide-1 receptor agonists, metabolic disease, metabolic dysfunction-associated steatotic liver disease, public health, umbrella review Citation Wu H, Zhang Z-H, Ye T, Chen J-N, Tung T-H and Zhu J-S (2026) Efficacy and safety of GLP-1 receptor agonists in patients with metabolic-associated fatty liver diseases: an umbrella review

Clinical trials have demonstrated reductions in hemoglobin A1c levels and weight loss that vary by dose and populationwith higher doses (such as Wegovy 2.4 mg) achieving approximately 15% weight loss in obesity trials, with more modest effects at lower doses used for diabetes

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