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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)

The article says this class is most appropriate for adults with a BMI of 27 or above who have a weight-related comorbidity, a BMI of 30 or above without one, or type 2 diabetes

Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide