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Recent investigations have demonstrated that KD enhances the expression of BDH1 in the kidneys of both humans and mice, which in turn increases the metabolic flux of BHB, AcAc, succinate, and fumarate, while inhibiting the nuclear translocation of Nrf2
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In the NNMT literature it appears as 5-amino-1MQ, 5A-1MQ, or NNMTi when referring to the selective, substrate-site-targeting inhibitor series
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