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The first published case of a significant tirzepatide injection site reaction described a progressive rash that enlarged over several days after administration, eventually covering the entire lower abdomen before resolving approximately one month after discontinuation

Galgano S, Conway L, Maggio F, Di, Farthing K, Dalby N, Fellows A et al

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The public can obtain it from grey-market labs, but no company can recoup the cost of a large, expensive human trial, because the moment it was proven to work, every grey-market lab on earth would sell the identical molecule for a fraction of the price, having spent nothing on research