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Preclinical work, predominantly from Sikiric and colleagues, has examined its activity in gastrointestinal ulcer models, tendon and ligament repair models, and endothelial/VEGF (vascular endothelial growth factor)-linked angiogenesis pathways

The peptide increases collagen fiber organization and cross-linking, producing repairs that more closely resemble healthy tendon structure rather than disorganized scar tissue

(More information) Lipoic acid is a direct antioxidant, although any increase in radical scavenging activity in vivo is likely transient

Liu P, Tian W, Tao S, Tillotson J, Wijeratne EMK, Gunatilaka AAL, et al