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Novo leadership pointed to the open-label design as a source of bias, suggesting that investigators, many of whom were already familiar and comfortable with Tirzepatide, may have pushed patients more aggressively on the Lilly arm
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A firm, non-tender nodule that appears within 24 hours and gradually softens over 57 days represents localized fibrosis from chemical irritation
Sulfur burping , one of the more unpleasant side effects, peaks for some researchers during this dose transition and typically resolves within two to three weeks
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