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The peptide incorporates specific amino acid substitutions at key positions to enhance stability against enzymatic degradation while preserving high affinity for the GHRH receptor
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Lett Drug Des Discov 15(6):612620
Preparation and characterization of OA-NPs@OA The OA-conjugated HA copolymers linked by disulfide bonds were synthesized based on our previous report and characterized via 1 H Nuclear Magnetic Resonance (NMR, Avance , Bruker, Germany), Fourier Transform Infrared Spectroscopy (FTIR, Nicolet iS50, Thermo Fisher, USA), Ultraviolet-Visible Spectroscopy (UV-Vis, Evolution300, Thermo Fisher, USA), X-Ray Diffraction (XRD, D8 ADVANCE Da Vinci, Bruker, Germany), Differential Scanning Calorimetry (DSC, DSC214, Thermo Fisher, USA), and Thermogravimetric Analysis (TGA, TG209, Thermo Fisher, USA)
