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retatrutide adds GCGR as a third target

Christopher McGowan, MD, a gastroenterologist and obesity medicine specialist, told Medical News Today that: Losing weight at the expense of lean muscle can lead to future problems, including reduced basal metabolic rate, decreased strength, fitness, and tone, reduced bone density, and an increased risk of weight recurrence

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An enzyme called g lutathione peroxidase then sparks the conversion of reduced glutathione to oxidized glutathione, a free radical itself