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Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

For the gallbladder and surrounding hepatobiliary tissues, these mechanisms translate into better local microcirculation, reduced oxidative and inflammatory stress, and enhanced cellular energy metabolism, all of which support intrinsic physiological processes governing bile concentration, smooth muscle contractility, and tissue resilience

Strategic Hydration: Drink water consistently throughout the day, rather than chugging it all at once

Vitale G, Pellegrino G, Vollery M, Hofland LJ