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Yes, but theres no pharmacological rationale for combining them both activate overlapping melanocortin receptors (MC3R and MC4R), so co-administration simply increases the total agonist exposure without adding mechanistic diversity
And so, GLP-1 receptor agonists improve blood glucose control directly by promoting insulin secretion and indirectly by facilitating weight loss
doi: 10.1016/j.aprim.2016.06.009 69 WhyteMBShojaee-MoradieFSharafSEJacksonNCFieldingBHovorkaRet al
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