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The primary ones involve worsened side effects like nausea and a risk of hypoglycemia (low blood glucose levels), especially for those with diabetes

The action of GLP-1 and GIP on the pancreas causes a reduction in glucagon secretion that results in diminished hepatic glucose production

Their coordinated expression and activity are tightly regulated at transcriptional and post-transcriptional levels, often in response to developmental cues, environmental stimuli, and hormonal signals

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