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In another study, 45 patients with poorly controlled type 2 diabetes (mean HbA1c, 8.4%) were randomized to canagliflozin, liraglutide, or both on top of their existing treatment regimen [14], and -cell glucose sensitivity was calculated by a mathematical model using data from oral glucose tolerance tests with frequent sampling for insulin and C-peptide
Because calorie intake ultimately drives changes in body composition, even modest appetite modulation could influence weight trends
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& Shu, L
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