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According to the bias assessment using the Cochrane Collaborations risk of bias tool, this study had a lower risk of bias
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ROS also trigger apoptosis by inactivating or increasing the ubiquitination of the pivotal anti-apoptotic protein Bcl-2 and by decreasing the intracellular levels of Bax and Bad 83,84 (Fig
Cons: two reconstitutions, two storage timelines, two injections per week (most community sources describe same-day separate-site injection)
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