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Statistical analyses were performed with Stata, v15.1 and p values 85 mmol/mol [10%]) and three showed that metformin caused little or no reduction in glycogenolysis and no change in the rate of gluconeogenesis (ESM Table 2)

Dosing started low and escalated gradually every four weeks, following the 'start low, go slow' protocol that reduces gastrointestinal side effects during the adjustment period

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Cell Tissue Bank 24(1):125137 Withaar C, Meems LMG, Nollet EE, Schouten EM, Schroeder MA, Knudsen LB, Niss K, Madsen CT, Hoegl A, Mazzoni G et al (2023) The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF