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Blood glucose, food intake, and major tissues including brown adipose, liver, and spleen weights were similar between RETA and SEMA, yet RETA uniquely reduced adiposity and delayed tumor latency suggesting that targeting a single receptor GLP1R was effective for many physiologic and metabolic benefits, but the additional agonism of GIPR and GPCR by RETA uniquely impacted adiposity, tumor onset, and tumor progression
Instead, it requires a holistic approach: eating a well-balanced diet, engaging in regular physical activity, getting adequate sleep, managing stress, and more
The Cox proportional hazards model was used to calculated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for outcomes associated with the use of GLP-1 RAs