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This was further confirmed in vitro using human vascular endothelial cells

[99] A person with cobalamin C disease, a rare autosomal, recessive, inheritance disease which results in combined methylmalonic aciduria and homocystinuria), [100] can be treated with intravenous or intramuscular hydroxocobalamin

These longer cycles require more careful monitoring and may benefit from slight dose reductions in weeks 13-16 to maintain receptor sensitivity

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