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Neuroprotective actions of vitamin C related to decreased lipid peroxidation and increased catalase activity in adult rats after pilocarpine-induced seizures

doi: 10.1007/s00394-014-0811-z 209

This modulation shifts the balance from pro-inflammatory M1 to anti-inflammatory M2 phenotypes [90], which is characterized by up-regulated anti-inflammatory cytokines (IL-4, IL-10 and TGF-), neurotrophic factors, and enzymes like arginase 1 and HO-1, which enhance the ROS detoxification and the phagocytic clearance of neurotoxic debris, including myelin fragments [91]

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