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Patients discontinuing semaglutide should work with healthcare providers to implement a structured discontinuation plan including nutrition guidance, regular physical activity (particularly resistance training to preserve lean muscle mass), and behavioral strategies to support weight maintenance and metabolic health
Unlike other incretin-based drugs such as Eli Lillys ZEPBOUND (tirzepatide), which activates both GLP-1 and GIP receptors, MariTide activates GLP-1 while blocking GIP
methionine, one of the key ingredients, may aggravate metabolic acidosis and a compromised liver may be unable to properly metabolize the compounds
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