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Starting Dose and Gradual Dose Adjustment Management is typically initiated at a lower dose and gradually increased to minimise gastrointestinal side effects and improve tolerability, as directed by the doctor
As de novo synthesis of ceramide is located in the ER, which is absent in erythrocytes, it is thus assumed that erythrocytic ceramide should directly originate from the hydrolysis of sphingomyelin
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Since glucose is the brains primary fuel, it should respond to a severe glucose deficiency
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