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Unintentional weight loss beyond what tirzepatide would explain: If you are losing weight faster than expected (beyond the typical tirzepatide weight loss timeline ), particularly with persistent heartburn, there may be an underlying condition that needs investigation
During organogenesis, lower doses approximately 0.1 to 1 times the clinical dose caused delayed skull ossification in rats
Tirzepatide is largely undetectable in breast milk at doses up to 5 mg, with less than 0.02% of the maternal dose appearing in milk over 28 days
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