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4 Primary research approaches Fig
When combined, they help boost each others effectiveness
GLP-1RA can reduce ectopic fat through appetite suppression and weight loss, improving insulin sensitivity, enhancing fatty acid oxidation, through anti-inflammatory and directly through tissue-specific action via GLP-1 receptors in liver, heart, pancreas and brain [72,73,74,75]
Gastrointestinal side effects such as nausea, heartburn, and constipation may be severe
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