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Activation of these cells stimulates the secretion of somatostatin, a potent inhibitor that acts locally on neighboring -cells to suppress glucagon release (Zheng et al., 2024)
The problem is that oral or recombinant GH therapies carry their own risk profiles, and compounded secretagogues like ipamorelin are reaching patients faster than trial data can follow
As access improves and costs come down, more patients are asking whether a very low dose can preserve the appetite regulation and metabolic benefits they experienced at higher doses
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