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Resmetirom (Rezdiffra TM ), a liver-directed thyroid hormone receptor- (THR-) agonist, received accelerated FDA approval in March 2024 as the first agent specifically indicated for non-cirrhotic MASH with moderate-to-advanced fibrosis (F2-F3), based on the MAESTRO-NASH trial demonstrating MASH resolution and fibrosis improvement
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The increase peaks around week 24 and then partially declines at weeks 36 and 48 even while continuing treatment the heart adapts somewhat
Studies show comparable results to full-time bracing for appropriate candidates
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