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In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin
Routine consultation should occur when constipation persists beyond one week despite appropriate use of over-the-counter laxatives and lifestyle modifications
Digestive enzyme supplements work locally in the gut to break down nutrients and do not interact pharmacologically with semaglutide's systemic GLP-1 receptor mechanism
One important note: intense exercise can temporarily increase inflammation in Hashimoto's patients
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