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The therapeutic window for these antioxidants is also poorly defined, as excessive ROS scavenging can disrupt redox signaling
How might that matter for ulcerative colitis or other colitis states
Exposure to the drug induced a mitochondria-independent mode of cell death due to the induction of reactive oxygen species (ROS) through erastin-mediated activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
Carnitine and acylcarnitines are exchanged between different tissues as metabolic intermediates or signaling molecules, directly or indirectly affecting a variety of metabolic and biological pathways in almost all organs, and have broad impacts on interorgan communication and metabolic cooperation
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