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When osteoclast activity exceeds osteoblast (bone-building) activity the net result is loss of bone density.' Research supports this, as one trial found that taking semaglutide (one form of GLP-1) was associated with lower bone density and an increased rate of bone breakdown
doi: 10.1016/0026-0495(87)90153-3 58 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW
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Likewise, concurrent use of certain medicationsparticularly fluoxetine (OR = 5.236)substantially increases serious adverse event risk
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