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HER2 overexpression or pathway activation is exhibited in about 5% to 20% of CCAs, and 15% to 30% of gallbladder cancer, for which off-label fam-trastuzumab deruxtecan-nxki (Enhertu, for IHC 3+), trastuzumab/pertuzumab (Phesgo) and trastuzumab + tucatinib (Herceptin + Tukysa) are recommended for HER2+ tumors after disease progression
Cost, Access, and Practical Considerations Current Market Status As investigational compounds, cagrilintide and retatrutide are not yet available through standard pharmaceutical channels
However, some studies have safely used 2 to 12 milligrams daily
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