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After the same treatment, the mean fluorescence intensity was measured using a FACS Calibur flow cytometer (Becton-Dickinson, San Jose, USA)

The expression of intestinal endocrine Lcells is regulated by several key receptors activated by short chain fatty acids (SCFAs), specific endogenous cannabinoids and bile acids, and the activation of these receptors increases the secretion of key intestinal peptides, such as GLP-1, GLP-2 and polypeptide YY (PYY) (de Vos et al., 2022)

JCI Insight (2022)

Gs-protein activation also increases heart rate (chronotropy) by increasing phase 4 pacemaker currents in the sinoatrial node