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REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)
In some embodiments, the formulation contains 8-12 mg/ml cagrilintide
This led to the assumption that the primary receptors mediating weight loss for this target class were AMYRs, yet, dual agonists are reported to have higher efficacy than AMYR selective agonists 2,10,11,12
The hemoglobin depletion may reflect oxidative damage to hemoglobin molecules with methemoglobin formation, iron-heme disruption from lipid peroxidation of erythrocyte membranes, or impaired hemoglobin synthesis [50]
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