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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)
It gently exfoliates while calming pigment processes
Nitric Oxide Production: Glutamine can indirectly enhance nitric oxide production, improving blood flow and muscle nutrient delivery
So while this comparison raised questions about how the treatment stacks up against competitors, it doesnt necessarily affect its chances of approval
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