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This review highlights NAD+ as a central regulator of energy metabolism, mitochondrial function, and cellular repair, demonstrating that age-related declines in NAD+ may contribute to chronic disease, while supplementation with NAD+ boosters shows potential for reducing age-related decline and disease

DOI: 10.1056/NEJMoa2206038 PMID: 35658024 Thomas MK, Nikooienejad A, Bray R, et al

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Supplementation may be beneficial during physiological stress and may also support a healthy intestinal lining, immune health, and lean muscle mass