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Treatment typically begins at a low dose with incremental increases every 4 weeks until reaching the maintenance dose or the maximum tolerated dose
To the remaining sample, 1.4 mL of a 10:1 chloroform:methanol solvent was added, and samples were thoroughly mixed using a vortexer and centrifuged (15 min, 2000 rpm, 0 C)
Like all medications, these can have side effects
However, modern evidence reveals that the gustatory system is a dynamic neuroendocrine system, crucial for nutritional sensing, metabolic regulation, and behavioral adaptation ( Built on this paradigm, a growing body of evidence indicates that GLP-1 acts beyond its classical endocrine role, directly influencing the gustatory system
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