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Bile acids also promote colonic water secretion, through TGR5-mediated activation of adenylate cyclase, which stimulates chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) (174)

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Some patients report that the unpleasant taste becomes less bothersome over time, even if it does not disappear entirely, as they become accustomed to the sensation

Statements Author contributions MI: Conceptualization, Data curation, Funding acquisition, Methodology, Software, Writing original draft