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The semaglutide plateau guide and information on early non-response to semaglutide provide additional context for people evaluating their options across the GLP-1 class

doi:10.7860/JCDR/2016/18208.8127 If a good first response is seen, a second injection may be considered when the improvement from the first injection begins to taper off

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These compounds are not interchangeable even where outcomes might overlap: one targets hormonal signalling, the other fundamental cellular metabolism