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Hepatocyte growth factor decreases nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) activation to downregulate adhesion molecules such as ICAM-1/E-selectin on the endothelial cell surface ( In the context of brain injury, macrophages exert a pivotal role in the induction of the inflammatory response ( Hepatocyte growth factor ameliorates tissue damage and functional recovery after the acute phase in a mouse model of SCI by exerting anti-inflammatory effects through the diminution of LPS-activated macrophages and neutrophil infiltration ( It has also been shown that HGF stimulates macrophage differentiation in dendritic immune-suppressive cells, thus facilitating the induction of T lymphocyte regulators, associated with a pivotal role in anti-inflammation

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In preclinical studies on tissues like tendons and muscles, significant improvements in healing and function are often observed within a few weeks