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By binding to ghrelin receptors in the hypothalamus, it mimics its functions, which are primarily reflected in the stimulation of appetite and the secretion of growth hormone
We also examined gene expression changes induced by C1-27 in HCT116 cells after 4 and 24 h treatment to observe the early and late response to GSTO1 inhibition, respectively (Supplementary Tables 1417 and 2023)
In addition to the rapid and long-lasting antidepressant response, boosting mitochondrial metabolism of LAC leads to the amelioration of specific cognitive domains [46, 47], and promotes behavioral resilience at the social defeat stress (SDS) paradigm [27]
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