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First, GLP-1Ra influenced lipid homeostasis by promoting fat breakdown, energy balance, and metabolic adaptation

At peripheral levels, the administration of GLP-1 RA regulates follicular proliferation and apoptosis-induced follicular atresia of the granulosa cells, a key component of the dominant follicle selection, possibly contributing to the oocyte maturation in PCOS

Semaglutide is an FDA-approved medication originally used to treat type 2 diabetes but now also prescribed for weight management

Spotting or irregular bleeding has not been identified as a common side effect, though some women report cycle changes whilst using GLP-1 medicines