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Taken these findings together, an early postoperative, physiological increase of GLP-2 plasma concentrations in all patients can be observed, regardless of the resected liver volume, indicating an upregulation during liver regeneration, timely persisting in resections of greater extent
In islet alpha cells, GLP-1(936) led to inhibition of Ca 2+ entry via voltage-gated Ca 2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049
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