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Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats
A broad, indicative timeline to be interpreted with caution may look as follows: Early weeks of treatment: Fatigue may be most noticeable, coinciding with appetite suppression and initial gastrointestinal adjustment
Adjusting the dose and frequency is key in the maintenance phase
Thus, structures of glutathionylated glutaredoxins 31,43,44,45 most likely resemble enzyme species F, whereas similar structures of complexes between reduced glutaredoxin and GSH with longer sulfursulfur distances 24,46 do not represent the interaction with GSH (but probably also resemble species F)
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