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These changes were paralleled by marked decreases in total, abdominal, leg, and arm fat percentage, along with increases in FFM and total body muscle percentage

That decline is part of why it's drawn research interest in the first place: if a molecule occurs naturally and its levels drop as tissue repair capacity drops, it becomes a reasonable candidate for studying repair signaling directly

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10.1007/s11306-022-01880-0 17 FiorilloA.ColottiG.ExertierC.LiuzziA.SeghettiF.SalernoA.et al (2022)