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Retatrutide is a synthetic peptide classified as a triple agonist peptide because it stimulates the receptors for glucosedependent insulinotropic polypeptide (GIP), glucagonlike peptide1 (GLP1) and glucagon (GCGR)

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The brain, mainly the hypothalamus, integrates these gut-derived signals, along with others, to coordinate the regulation of food intake, energy expenditure, and glucose homeostasis 14,15

This review comprehensively overviews the pathophysiology of AKI and further elucidates the pathogenesis of AKI attributed to both clinical conditions and its treatments