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For instance, BDNF up-regulation in chronic epilepsy models exhibits dualistic properties, potentially exacerbating hyperexcitability through TrkB receptor-mediated potentiation of glutamatergic synapsesa phenomenon not yet systematically evaluated in VD intervention studies [102]
Bioavailability and absorption The bodys ability to absorb and utilize these amino acids differs significantly: L-Citrulline: L-citrulline is not subject to the same rapid breakdown as L-arginine, leading to better absorption and sustained increases in L-arginine and nitric oxide levels
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