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This mouse model is more physiological than the mouse model with overexpressing receptors, since the receptor level is under the normal promoter control
The drug has been approved for treating obesity by major regulatory authorities, including the FDA in the United States and the EMA in Europe in June 2021 and January 2022, respectively
A 2024 study in Nature Cell Discovery used cryo-electron microscopy to show how Retatrutide binds and activates all three receptors, providing structural evidence for its combinatorial agonism
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