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When compared to those taking topiramate, GLP-1 users were: 48% less likely to start valproate 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies 35% less likely to start tricyclic antidepressants 23% less likely to start the class of drugs called gepants However, there was no significant difference between the two groups, and the need to begin taking beta-blockers

"It seems best to treat constipation, but some people find it beneficial for any sort of abdominal symptom," says William Chey, MD, chief of the division of gastroenterology at the University of Michigan Medical Center in Ann Arbor

As of April 21, 2026, regulatory status for many peptides remains under review and may change as additional data and guidance become available

The MDL allows cases with shared factual issues to move through coordinated discovery and pretrial rulings while preserving each plaintiffs individual Ozempic claim