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Mechanism Differences Unlike retinoids or alpha hydroxy acids (AHAs) that primarily work by accelerating cell turnover and exfoliation, which can sometimes compromise the skin barrier and cause irritation, GHK-Cu supports the skin's natural repair processes
International Journal of Dermatology , 52(S1), 39
The solvent Another possible cause of painful B12 injections is the solvent used to dissolve the B12 in the vial
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