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The reduced dose provides ongoing support for skin health, immune function, and systemic inflammation control without the intensity of the optimization phase
In about 17,600 adults with obesity and established cardiovascular disease but no diabetes, semaglutide cut major cardiovascular events by 20% over roughly 40 months. This is a secondary-prevention result in people who already had heart disease
Muscle: 250 to 500 mcg once or twice daily, subcutaneous near the muscle, 4 to 8 weeks
The standard recommendation is one 500 mcg capsule twice daily on an empty stomach
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